3, 5 The clinical presentation of osteosarcomas in the jaws and long bones is also different. In JOS, the average age of onset is 10 to 20 years later, distant metastases occur less frequently, the histopathologic variables are more favorable, and the survival rates are higher. 1 - 4 The biological behavior of jaw osteosarcoma (JOS) differs from osteosarcomas involving long bones. Osteosarcoma occurring in the jaws is rare, constituting only 6% to 7% of all osteosarcomas. Osteosarcoma is a primary malignant bone tumor, which typically affects the metaphyseal growth plates in the femur, tibia, and humerus. Radiation therapy was not associated with improved survival, reflecting the controversy surrounding its use in clinical literature. Determinants of survival include age at diagnosis, stage at presentation, tumor size, and surgical therapy. Tumor size was not significant for OS (HR, 1.00 95% CI, 1.00-1.01 but significant for DSS (HR, 1.01 95% CI, 1.00-1.01 ).Ĭonclusions and Relevance To our knowledge, this is the largest study to date investigating prognostic factors for survival in patients diagnosed with osteosarcoma of the jaws. Multivariate Cox regression analysis revealed that independent predictors of OS and DSS included age at diagnosis (hazard ratio, 1.03 95% CI, 1.02-1.04 for OS and HR, 1.03 95% CI, 1.02-1.05 for DSS) stage at presentation (HR, 1.37 95% CI, 1.10-1.71 for OS and HR, 1.34 95% CI, 1.01-1.76 for DSS) and surgical resection (HR, 0.31 95% CI, 0.16-0.60 for OS and HR, 0.22 95% CI, 0.09-0.56 for DSS). Kaplan-Meier analysis demonstrated an overall survival (OS) and disease-specific survival (DSS) of 53% and 62%, respectively, at 5 years and 35% and 54%, respectively, at 10 years. Results A total of 541 patients diagnosed with osteosarcoma of the jaws were identified (49.9% male and 50.1% female, with a mean age of 41.3 years). Main Outcomes and Measures Overall and disease-specific survival.
Objective To investigate the epidemiologic characteristics and prognostic factors for survival in patients diagnosed with osteosarcoma of the jaws.ĭesign, Setting, and Participants A retrospective, population-based cohort study of 541 patients in the SEER tumor registry diagnosed with osteosarcoma of the jaws from 1973 through 2011 were reviewed.Įxposures Patients had been treated with surgery, radiation, both, or neither.
We used data from the population-based national Surveillance, Epidemiology and End Results (SEER) cancer registry to determine the epidemiology and prognostic factors associated with osteosarcoma of the jaws. The literature on these tumors is limited to case reports and small case series mostly from single institutions. Importance Osteosarcoma of the jaws is rare and clinically distinct from osteosarcoma of the long bones of the body with different treatment and outcomes.
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